Release of sodium diclofenac from vehicles prepared with hydrogenated soya lecithin and methyl palmitate.
نویسندگان
چکیده
منابع مشابه
Liposomes from hydrogenated soya lecithin formed in sintered glass pores.
Possible complete closure of hydrophilic drug solutions in liposomes with required dimensions is the aim of variety liposome techniques. The ease of separating medication-loaded liposomes from liposome suspension to achieve an appropriate drug concentration in the final preparation is also desired. This paper describes the use of liposome preparation method, called reverse-phase evaporation, wh...
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Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...
متن کاملInvitro Release Study of Sodium Salicylate from Lecithin Based Phospholipid Microemulsions
Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...
متن کاملRat percutaneous transport of diclofenac and influence of hydrogenated soya phospholipids.
Poor penetration of diclofenac through in vitro rat dorsal skin including subcutaneous tissue was observed. The poor penetration of diclofenac seemed to be predominIntly due to the poor permeability of the stratum corneum. Hydrogenated soya phospholipids (phospholipid) in aqueous gel form increased the penetration of diclofenac in the in vitro study, by increasing diclofenac transport through t...
متن کاملPharma Science Monitor an International Journal of Pharmaceutical Sciences in Vitro Release of Diclofenac Sodium from Different Topical Vehicles
There is currently a great deal of world-wide interest in the field of transdermal drug delivery and, consequently, broad classes of drugs are being evaluated for percutaneous absorption potential. The advantages of this mode of drug administration are numerous, the patient convenience and therapeutic optimization of using patch transdermal systems being major positive features. The in vitro re...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.750